Publications by authors named "Alexandra D Lieberman"
Article Synopsis
- African American men are diagnosed with and die from prostate cancer at higher rates than Caucasian men, and genetic differences, specifically higher rates of CDK12 somatic mutations, may contribute to this disparity.
- A study analyzing ctDNA in metastatic castration-resistant prostate cancer (mCRPC) between these two groups found that African American men exhibited significantly more pathogenic mutations and frameshift mutations after treatment with abiraterone and/or enzalutamide.
- The results suggest that the genetic differences observed in African American men could have implications for targeted treatments and personalized medicine in managing prostate cancer.
