Publications by authors named "Alexandra Coomans de Brachene"
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Synopsis of recent research by authors named "Alexandra Coomans de Brachene"
- Recent research by Alexandra Coomans de Brachene focuses on the role of inflammation and cytokines, particularly TYK2 and interferons, in the pathology of type 1 diabetes (T1D), evaluating therapeutic strategies to mitigate beta cell loss and inflammation.
- Notable findings include the pharmacological inhibition of TYK2 reducing islet inflammation and delaying T1D onset, and the characterization of specific cytokine responses in human pancreatic beta cells that may be targeted for therapeutic intervention.
- The research also highlights the potential of non-pharmacological interventions like exercise in protecting beta cells, alongside investigating the complex interactions between viral infections, immune responses, and the innate signaling pathways involved in T1D progression.
