Synopsis of recent research by authors named "Alexandra Chirino"
- Alexandra Chirino's recent research extensively explores the interaction between the oral microbiome and SARS-CoV-2, demonstrating how certain compounds can inhibit the virus's infection mechanisms, highlighting a potential new therapeutic approach.
- She has investigated the implications of SF3B1 mutations in cancer, revealing that these mutations make certain cells sensitive to XPO1 nuclear export inhibitors, suggesting a targeted therapy strategy for high-risk myelodysplastic neoplasms.
- Additionally, her work addresses the challenges posed by acquired drug-resistant mutations in Bruton's tyrosine kinase (BTK) related to chronic lymphocytic leukemia, contributing to the development of novel degrader therapies that target both BTK and IKZF1/3 mutations.
