Publications by authors named "Alexandra C McHale-Matthews"
Article Synopsis
- The study investigates the presence of immature neurons in the paralaminar nucleus of the amygdala in macaques during different developmental stages and under varying maternal conditions.
- It finds that adolescent macaques have fewer immature neurons and more mature neurons compared to infants, and suggests that some neurons exit the PL as they mature.
- Maternal separation in infant macaques does not affect neuron counts but correlates with changes in TBR1 mRNA levels, indicating that stress may hinder the maturation of these neurons.
In human and nonhuman primates, the amygdala paralaminar nucleus (PL) contains immature neurons. To explore the PL’s potential for cellular growth during development, we compared PL cells in 1) infant and adolescent macaques (control, maternally-reared), and in 2) infant macaques that experienced separation from their mother in the first month of life. In maternally-reared animals, the adolescent PL had fewer immature neurons, more mature neurons, and larger immature soma volumes compared to infant PL.
View Article and Find Full Text PDF