Publications by authors named "Alexandra Aybar-Torres"
Article Synopsis
- - The study highlights the growing awareness of a specific gene's role in tissue inflammation and cancer immunotherapy, focusing on common alleles found predominantly in East Asians and Africans, which may influence immune responses.
- - Research conducted using knock-in mice reveals that certain alleles can prevent cell death caused by STING1 activation, leading to increased T-regulatory cells and demonstrating a potential link between STING1 and tissue inflammation.
- - The findings suggest that understanding genetic variations in human populations is crucial for developing targeted STING1 immunotherapy, emphasizing the need to consider genetic diversity in modern human health studies.
The significance of STING (encoded by the gene) in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human alleles R71H-G230A-R293Q ( and G230A-R293Q () are carried by ~60% of East Asians and ~40% of Africans, respectively. Here, we examine the modulatory effects of alleles on STING-associated vasculopathy with onset in infancy (SAVI), an autosomal dominant, fatal inflammatory disease caused by gain-of-function human mutations.
View Article and Find Full Text PDFMPYS/STING (stimulator of IFN genes) senses cyclic dinucleotides (CDNs), generates type I IFNs, and plays a critical role in infection, inflammation, and cancer. In this study, analyzing genotype and haplotype data from the 1000 Genomes Project, we found that the R71H-G230A-R293Q (HAQ) MPYS allele frequency increased 57-fold in East Asians compared with sub-Saharan Africans. Meanwhile, the G230A-R293Q (AQ) allele frequency decreased by 98% in East Asians compared with sub-Saharan Africans.
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