Publications by authors named "Alexandra Andrews"
Article Synopsis
- Chemical and physical stabilities are crucial in pharmaceutical development, with chemical stability involving potency and degradation, while Thioflavin-T measures physical stability.
- To enhance the efficiency of stability studies, a machine learning-based model is proposed to predict chemical stability based on formulation conditions and aggregation curves.
- The study achieved high accuracy in predicting total degradation and potency using machine learning techniques, highlighting the link between physical and chemical stability in peptides.
Article Synopsis
- Peptides and proteins can adopt various complex structures, which can lead to harmful forms like aggregates and fibrils that affect drug development and disease.
- Liraglutide, a drug for diabetes, forms oligomers that can be stabilized by factors like pH and solvents, and these oligomers can influence the drug's stability and effectiveness.
- Our research highlights how Liraglutide's "oligomer memory effect" from its synthesis process is crucial for understanding its behavior, which has implications for the entire drug development process.
Goals Of Work: As medical care for cancer has become more specialized in diagnosis, treatment has become more technical and fragmented. In order to help cancer patients and their families, we developed a coordinated program called the Stanford Cancer Supportive Care Program (SCSCP) at the Center for Integrative Medicine at Stanford Hospital and Clinics. The Stanford Cancer Supportive Care Program was initiated in 1999 to provide support for cancer patients, addressing the need for improved physical and emotional well-being and quality of life.
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