Functional Activity of Isoform 2 of Human eRF1.

Eukaryotic release factor eRF1, encoded by the gene, recognizes stop codons and induces peptide release during translation termination. produces several different transcripts as a result of alternative splicing, from which two eRF1 isoforms can be formed. Isoform 1 codes well-studied canonical eRF1, and isoform 2 is 33 amino acid residues shorter than isoform 1 and completely unstudied.