Publications by authors named "Alexandr Gostev"
Background: Fasciotomy can increase the mobility of the superficial femoral artery and decrease the incidence of stent fractures. This study aimed to compare the long-term patency of drug-eluting nitinol stents with and without fasciotomy in patients with prolonged superficial femoral artery occlusions.
Methods: A randomized clinical trial was conducted in 60 (1:1) patients with long femoropopliteal steno-occlusive lesions >200 mm.
Objective: Aim of the study was to improve the immediate and long-term results of stenting of the superficial femoral artery in extended lesions with the changing of the biomechanics of superficial ffemoral artery and of the first portion of the popliteal artery.
Methods: Pilot randomized prospective single-center study were included 70 patients. Patients were randomized into two groups in 1 × 1 format for 35 people using the envelope method.
We examined the physicochemical properties and the biocompatibility and hemocompatibility of electrospun 3D matrices produced using polyurethane Pellethane 2363-80A (Pel-80A) blends Pel-80A with gelatin or/and bivalirudin. Two layers of vascular grafts of 1.8 mm in diameter were manufactured and studied for hemocompatibility ex vivo and functioning in the infrarenal position of Wistar rat abdominal aorta in vivo ( = 18).
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- The study investigates the physicochemical properties of vascular grafts (VGs) made from a mixture of Tecoflex, gelatin, and bivalirudin using electrospinning, comparing them to traditional e-PTFE grafts.
- After 24 weeks of implantation in Wistar rats, 94.5% of the Tec-GL-BV grafts remained occlusion-free, significantly outperforming the 66.6% occlusion-free rate of e-PTFE grafts.
- Additionally, the Tec-GL-BV grafts showed more neovascularization and less neointima thickness and calcification, indicating their potential advantages in clinical applications.