Selection of antitumor displayed peptides for the specific delivery of the anticancer drug lactaptin.

It has been previously demonstrated that lactaptin, the proteolytic fragment of human milk protein κ-casein, induces the death of various cultured cancer cells. The recombinant analog of lactaptin, RL2, effectively induces the apoptosis of mouse hepatocarcinoma-1 (HA-1) tumor cells and suppress the growth of HA-1 tumors and metastases . The antitumor drug Lactaptin developed on the basis of RL2 has been successful in preclinical trials.