Influence of folic acid and vitamin B12 supplementation on arsenic methylation: A double-blinded, placebo-controlled trial in Bangladeshi children.

Background: Inorganic arsenic is metabolized to monomethyl- (MMAs) and dimethyl- (DMAs) species via one-carbon metabolism (OCM); this facilitates urinary arsenic elimination. OCM is influenced by folate and vitamin B12 and previous randomized control trials (RCTs) showed that folic acid (FA) supplementation increases arsenic methylation in adults. This RCT investigated the effects of FA + B12 supplementation on arsenic methylation in children, a key developmental stage where OCM supports growth.

Lead-based paint detection using perovskite fluorescence and X-ray fluorescence.

Background: Ingestion of flakes of Pb-based paint by infants remains a global health hazard with life-long consequences. Pb-based paint was banned for residential use in the US and Western Europe decades ago but is still sold in many countries. This study evaluates the performance of a new kit for detecting exposed Pb-based paint relying on the formation of Pb-halide perovskite that fluoresces bright green under a UV flashlight after spraying a non-toxic reagent.

Widespread Pb contamination in urban backyard soils for >100 years identified in soil cores constrained by Pb and Cs.

Contaminated soil in urban residential areas is often overlooked as a source of childhood exposure to toxic levels of lead (Pb). We document mean Pb concentrations of 1200 ± 1000 mg/kg, three times the now outdated EPA soil hazard standard of 400 mg/kg, for 370 surface soils collected from 76 homes in the boroughs of Brooklyn and Manhattan of New York City. The mean Pb content of 250 ± 290 mg/kg Pb for 571 surface soils collected from tree pits and public parks was much lower.

Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh.

Introduction: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated associations between anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh.

Sulfate reduction accelerates groundwater arsenic contamination even in aquifers with abundant iron oxides.

Groundwater contamination by geogenic arsenic is a global problem affecting nearly 200 million people. In South and Southeast Asia, a cost-effective mitigation strategy is to use oxidized low-arsenic aquifers rather than reduced high-arsenic aquifers. Aquifers with abundant oxidized iron minerals are presumably safeguarded against immediate arsenic contamination, due to strong sorption of arsenic onto iron minerals.

The Pregnancy, Arsenic, and Immune Response (PAIR) Study in rural northern Bangladesh.

Background: Arsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the foetus, and maternal and infant acute morbidity.

Objectives: The Pregnancy, Arsenic, and Immune Response (PAIR) Study was designed to assess whether arsenic exposure and micronutrient deficiencies alter maternal and newborn immunity and acute morbidity following maternal seasonal influenza vaccination during pregnancy.

Population: The PAIR Study recruited pregnant women across a large rural study area in Gaibandha District, northern Bangladesh, 2018-2019.

Mass fluxes of dissolved arsenic discharging to the Meghna River are sufficient to account for the mass of arsenic in riverbank sediments.

Shallow (<30 m) reducing groundwater commonly contains abundant dissolved arsenic (As) in Bangladesh. We hypothesize that dissolved As in iron (Fe)-rich groundwater discharging to rivers is trapped onto Fe(III)-oxyhydroxides which precipitate in shallow riverbank sediments under the influence of tidal fluctuations. Therefore, the goal of this study is to compare the calculated mass of sediment-bound As that would be sequestered from dissolved groundwater As that discharges through riverbanks of the Meghna River to the observed mass of As trapped within riverbank sediments.

A mass-balance approach to evaluate arsenic intake and excretion in different populations.

Unless a toxicant builds up in a deep compartment, intake by the human body must on average balance the amount that is lost. We apply this idea to assess arsenic (As) exposure misclassification in three previously studied populations in rural Bangladesh (n = 11,224), Navajo Nation in the Southwestern United States (n = 619), and northern Chile (n = 630), under varying assumptions about As sources. Relationships between As intake and excretion were simulated by taking into account additional sources, as well as variability in urine dilution inferred from urinary creatinine.

Well-Switching to Reduce Arsenic Exposure in Bangladesh: Making the Most of Inaccurate Field Kit Measurements.

Well-switching programs in Bangladesh have successfully lowered arsenic exposure. In these programs, households switch from wells that are labeled "unsafe" to nearby wells labeled "safe," but these designations are usually based on inherently inaccurate field kit measurements. Here, we (a) compare the efficacy of field-kit measurements to accurate laboratory measurements for well switching, (b) investigate the potential impact on well switching of the chosen "safe" threshold, and (c) consider the possible benefits of providing more detailed concentration information than just "safe" and "unsafe.

Testing Homes for Potential Sources of Lead Exposure as a High-School Science Project.

High-school students tested soil, paint, and water for lead (Pb) in a total of 80 houses in their town of Pelham, New York, where blood-Pb data indicate relatively high levels of child exposure. All the samples were tested in the laboratory using established procedures but this was preceded by testing of soil and paint in the field with a kit by the students. The total Pb concentration in 32 of the 159 soil samples that were collected exceeded 400 ppm, the EPA standard for bare soil in residential areas where children play.

Assessment of Excess Mortality and Household Income in Rural Bangladesh During the COVID-19 Pandemic in 2020.

Importance: A slow or incomplete civil registry makes it impossible to determine excess mortality due to COVID-19 and difficult to inform policy.

Objective: To quantify the association of the COVID-19 pandemic with excess mortality and household income in rural Bangladesh in 2020.

Design, Setting, And Participants: This repeated survey study is based on an in-person census followed by 2 rounds of telephone calls.

Groundwater fluoride across the Punjab plains of Pakistan and India: Distribution and underlying mechanisms.

Chronic exposure from drinking well-water with naturally high concentrations of fluoride (F) has serious health consequences in several regions across the world including South Asia, where the rural population is particularly dependent on untreated groundwater pumped from private wells. An extensive campaign to test 28,648 wells was conducted across the Punjab plains of Pakistan and India by relying primarily on field kits to document the scale of the problem and shed light on the underlying mechanisms. Groundwater samples were collected from a subset of 712 wells for laboratory analysis of F and other constituents.

A mass-balance model to assess arsenic exposure from multiple wells in Bangladesh.

Background: Water arsenic (As) sources beyond a rural household's primary well may be a significant source for certain individuals, including schoolchildren and men working elsewhere.

Objective: To improve exposure assessment by estimating the fraction of drinking water that comes from wells other than the household's primary well in a densely populated area.

Methods: We use well water and urinary As data collected in 2000-2001 within a 25 km area of Araihazar upazila, Bangladesh, for 11,197 participants in the Health Effects of Arsenic Longitudinal Study (HEALS).

Soil arsenic but not rice arsenic increasing with arsenic in irrigation water in the Punjab plains of Pakistan.

Aim: Irrigating rice with groundwater can lead to As accumulation in soil and rice grains. Matched sets of irrigation water, paddy soil, and rice grains were collected to assess the scale of the problem in the Punjab plains of Pakistan.

Methods: From a total of 60 sites, irrigation water and rice grains as well as 103 soil samples were collected and analyzed in the laboratory.

Regulation of groundwater arsenic concentrations in the Ravi, Beas, and Sutlej floodplains of Punjab, India.

Recent testing has shown that shallow aquifers of the Ravi River floodplain are more frequently affected by groundwater arsenic (As) contamination than other floodplains of the upper Indus River basin. In this study, we explore the geochemical origin of this contrast by comparing groundwater and aquifer sand composition in the 10-30 m depth range in 11 villages along the Ravi and adjacent Beas and Sutlej rivers. The drilling was preceded by testing wells in the same villages with field kits not only for As but also for nitrate (NO ), iron (Fe), and sulfate (SO ).

Fallout of Lead Over Paris From the 2019 Notre-Dame Cathedral Fire.

The roof and spire of Notre-Dame cathedral in Paris that caught fire and collapsed on 15 April 2019 were covered with 460 t of lead (Pb). Government reports documented Pb deposition immediately downwind of the cathedral and a twentyfold increase in airborne Pb concentrations at a distance of 50 km in the aftermath. For this study, we collected 100 samples of surface soil from tree pits, parks, and other sites in all directions within 1 km of the cathedral.

Aquifer-Scale Observations of Iron Redox Transformations in Arsenic-Impacted Environments to Predict Future Contamination.

Iron oxides control the mobility of a host of contaminants in aquifer systems, and the microbial reduction of iron oxides in the subsurface is linked to high levels of arsenic in groundwater that affects greater than 150 million people globally. Paired observations of groundwater and solid-phase aquifer composition are critical to understand spatial and temporal trends in contamination and effectively manage changing water resources, yet field-representative mineralogical data are sparse across redox gradients relevant to arsenic contamination. We characterize iron mineralogy using X-ray absorption spectroscopy across a natural gradient of groundwater arsenic contamination in Vietnam.

Evaluation of a field kit for testing arsenic in paddy soil contaminated by irrigation water.

Rice is the primary crop in Bangladesh and rice yield is diminished due to the buildup of arsenic (As) in soil from irrigation with high-As groundwater. Soil testing with an inexpensive kit could help farmers target high-As soil for mitigation or decide to switch to a different crop that is less sensitive to As in soil. A total of 3,240 field kit measurements of As in 0.

Similar retardation of arsenic in gray Holocene and orange Pleistocene sediments: Evidence from field-based column experiments in Bangladesh.

Groundwater flow has the potential to introduce arsenic (As) in previously uncontaminated aquifers. The extent to which As transport is retarded by adsorption is particularly relevant in Bangladesh where low-As wells offer the best chance of reducing chronic exposure to As of a large rural population dependent on groundwater. In this study, column experiments were conducted with intact cores in the field to measure As retardation.

Recommended Sampling Intervals for Arsenic in Private Wells.

Geogenic arsenic in drinking water is a worldwide problem. For private well owners, testing (e.g.

Demand for Information on Environmental Health Risk, Mode of Delivery, and Behavioral Change: Evidence from Sonargaon, Bangladesh.

Millions of villagers in Bangladesh are exposed to arsenic by drinking contaminated water from private wells. Testing for arsenic can encourage switching from unsafe wells to safer sources. This study describes results from a cluster randomized controlled trial conducted in 112 villages in Bangladesh to evaluate the effectiveness of different test selling schemes at inducing switching from unsafe wells.

Arsenic contamination of Bangladesh aquifers exacerbated by clay layers.

Confining clay layers typically protect groundwater aquifers against downward intrusion of contaminants. In the context of groundwater arsenic in Bangladesh, we challenge this notion here by showing that organic carbon drawn from a clay layer into a low-arsenic pre-Holocene (>12 kyr-old) aquifer promotes the reductive dissolution of iron oxides and the release of arsenic. The finding explains a steady rise in arsenic concentrations in a pre-Holocene aquifer below such a clay layer and the repeated failure of a structurally sound community well.

New Approaches to Identifying and Reducing the Global Burden of Disease From Pollution.

Pollution from multiple sources causes significant disease and death worldwide. Some sources are legacy, such as heavy metals accumulated in soils, and some are current, such as particulate matter. Because the global burden of disease from pollution is so high, it is important to identify legacy and current sources and to develop and implement effective techniques to reduce human exposure.

Does Involving Parents in Soil Sampling Identify Causes of Child Exposure to Lead? A Case Study of Community Engagement in Mining-Impacted Towns in Peru.

Over a million people in Peru may be exposed to lead (Pb) due to past or present mining-related activities; however, neither soil Pb nor blood Pb are routinely monitored throughout the country. Because little is known about Pb contamination in smaller mining-impacted towns, soil Pb was mapped in four such towns with a portable X-ray fluorescence analyzer in 2015. The roadside mapping delineated hotspots of highly contaminated soil (1,000-6,000 mg/kg Pb) in two of the towns.