Publications by authors named "Alexander Z Wang"
RNAs represent a class of programmable biomolecules capable of performing diverse biological functions. Recent studies have developed accurate RNA three-dimensional structure prediction methods, which may enable new RNAs to be designed in a structure-guided manner. Here, we develop a structure-to-sequence deep learning platform for the de novo generative design of RNA aptamers.
View Article and Find Full Text PDFBackground: Sensory disability in older adults is associated with increased rates of depressive symptoms and loneliness. Here, we examined the impact of hearing, vision, and olfaction disability on mental health outcomes in older US adults.
Methods: We studied respondents from the first three rounds (2005/6, 2010/11, and 2015/16) of the National Social Life, Health and Aging Project, a nationally representative, longitudinal study of older US adults.
Objective: The aim of this study is to evaluate the association between race and the treatment of laryngeal dysplasia and early-stage laryngeal squamous cell carcinoma (LSCC).
Study Design: Retrospective Cohort Study.
Setting: Large multispecialty academic medical center.
Article Synopsis
- - The study addresses the challenges of using engineered adeno-associated viral vectors (AAVs) for targeting specific cell types by developing a new method called USeqFISH, which allows for high-resolution spatial profiling of RNA in tissues.
- - USeqFISH was used to analyze the transduction patterns of six different systemic AAVs in mouse brain regions, revealing unique preferences for certain cell subtypes, such as AAV-PHP.N favoring excitatory neurons.
- - The method also facilitates the profiling of regulatory elements within AAV genomes and shows promise for applications in studying gene delivery in non-human primates.