Publications by authors named "Alexander Yu Sidorenko"
In this work kaolinite nanotubes (KNT) were obtained from commercial kaolin AKF-78 (Uzbekistan) by starting material sequential intercalation by DMSO and methanol, followed by treatment with a cetyltrimethylammonium chloride solution. Acid functionalization of KNT for catalytic applications was successfully performed for the first time using a two-step treatment with piranha solution (HSO-HO), which resulted in the removal of organic impurities as synthetic artifacts and an increase in specific surface area by 3.9 times (up to 159 m g), pore volume by 1.
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- * This study explores reactions between salicylic aldehydes and a specific monoterpene derivative, resulting in various chiral polycyclic products, with some being novel ring structures.
- * The results indicate that the type of acid catalyst used and the reaction conditions significantly influence the product outcomes, and the study includes detailed mechanistic insights supported by experimental and computational methods.
Article Synopsis
- Researchers discovered two new types of TDP1 inhibitors that can effectively inhibit the TDP1 enzyme, crucial for DNA repair, at low concentrations, with the strongest compound showing an IC value of 0.65 μM.
- The inhibitors were synthesized from monoterpene compounds and they demonstrated a synergistic effect when tested with the cancer drug topotecan in HEK293FT cells with functional TDP1.
- This synergy suggests that using non-toxic inhibitors alongside existing cancer therapies can improve treatment effectiveness while minimizing harmful side effects.