Amisulpride Decreases Tau Protein Hyperphosphorylation in the Brain of OXYS Rats.

Aim: In this study, OXYS rats of three ages (1, 3, and 6 months), a proven model of Alzheimer's disease (AD), at various stages of disease progression were used to thoroughly study the effects of amisulpride on behavior and tau protein phosphorylation.

Background: With the growing number of patients with AD, the problem of finding a cure is very acute. Neurodegeneration in AD has various causes, one of which is hyperphosphorylation of tau protein.

The brain serotonin system in autism.

Autism spectrum disorders (ASDs) are among the most common neurodevelopmental diseases. These disorders are characterized by lack of social interaction, by repetitive behavior, and often anxiety and learning disabilities. The brain serotonin (5-HT) system is known to be crucially implicated in a wide range of physiological functions and in the control of different kinds of normal and pathological behavior.

Serotonin 5-HT receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice.

Heterodimerization between 5-HT and 5-HT receptors seems to play an important role in the mechanism of depression and antidepressant drug action. It was suggested that the shift of the ratio between 5-HT /5-HT hetero- and 5-HT /5-HT homodimers in presynaptic neurons toward 5-HT /5-HT homodimers is one of the reasons of depression. Consequently, the artificial elevation of 5-HT receptor number in presynaptic terminals might restore physiological homo-/heterodimer ratio resulting in antidepressive effect.

Effects of a in the Hippocampus on Behavior, the Serotonin System, and BDNF.

The serotonin 5-HT receptor is one of the most abundant and widely distributed brain serotonin (5-HT) receptors that play a major role in the modulation of emotions and behavior. The 5-HT receptor gene () is under the control of transcription factor Freud-1 (also known as ). Here, using adeno-associated virus (AAV) constructs in vivo, we investigated effects of a in the hippocampus of C57BL/6J mice on behavior, the brain 5-HT system, and brain-derived neurotrophic factor (BDNF).

Genetic Background Underlying 5-HT Receptor Functioning Affects the Response to Fluoxetine.

The influence of genetic background on sensitivity to drugs represents a topical problem of personalized medicine. Here, we investigated the effect of chronic (20 mg/kg, 14 days, i.p.