Publications by authors named "Alexander Y G Yip"
Article Synopsis
- The intestine serves as a key area for the growth of carbapenem-resistant Enterobacteriaceae (CRE), which can lead to serious infections.
- Use of broad-spectrum antibiotics disrupts normal gut bacteria, allowing CRE to thrive by increasing available nutrients and reducing substances that inhibit their growth.
- The study demonstrates that antibiotics not only lower the levels of beneficial gut microbes but also enrich nutrients that CRE can use for growth, making it easier for them to colonize the intestine.
The human gut microbiota can restrict the growth of pathogens to prevent them from colonizing the intestine ('colonization resistance'). However, antibiotic treatment can kill members of the gut microbiota ('gut commensals') and reduce competition for nutrients, making these nutrients available to support the growth of pathogens. This disturbance can lead to the growth and expansion of pathogens within the intestine (including antibiotic-resistant pathogens), where these pathogens can exploit the absence of competitors and the nutrient-enriched gut environment.
View Article and Find Full Text PDFUse of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis.
J Allergy Clin Immunol
November 2021
Background: Regulatory bodies recommend that all patients at risk of anaphylaxis be prescribed 2 epinephrine autoinjectors, which they should carry at all times. This is in contrast to some guidelines. The proportion of anaphylaxis reactions that are treated with multiple doses of epinephrine has not been systematically evaluated.
View Article and Find Full Text PDF