Publications by authors named "Alexander Xiao"
Purpose: To investigate the molecular characteristics of and potential for precision medicine in KRAS wildtype pancreatic ductal adenocarcinoma (PDAC).
Patients And Methods: We investigated 27 patients with PDAC at our institution. Clinical data were obtained via chart review.
Objective: To explore patterns in Medicare reimbursement for wasted oncologic and hematologic infusion drugs from 2017 to 2020 and estimate the savings that implementation of the Infrastructure Investment and Jobs Act (IIJA) would have had.
Methods: Using the publicly available Medicare Part B Discarded Drug Units database, we analyzed reimbursement data for discarded antineoplastic and hematology therapies from 2017 to 2020.
Results: Medicare Part B utilization data was extracted for 77 therapies.
Defecatory disorders in patients with type 1 diabetes and chronic constipation.
Neurogastroenterol Motil
August 2023
Background And Objectives: Chronic constipation (CC) may be caused by defecatory disorders (DDs) and associated with reduced rectal sensation. Among patients with type 1 diabetes (T1D) and CC (T1DCC patients), the prevalence of DDs and reduced rectal sensation is unknown. We sought to compare complications of T1D, anorectal dysfunction, and CC symptoms, among T1DCC patients with versus without a DD.
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- The treatment of multiple myeloma (MM) has greatly improved with the FDA approving over 15 new drugs in the last 20 years, alongside autologous stem cell transplantation, leading to better survival rates for patients.
- Enhanced knowledge of the bone marrow (BM) and immune microenvironment has spurred the development of potent immunotherapies that show high response rates, particularly for resistant cases of MM.
- Despite advancements, treating MM remains difficult, especially in high-risk situations, necessitating further research on the BM microenvironment to create therapies that can provide long-lasting control or potential cures for the disease.
Purpose: The purpose of this study is to evaluate the perspectives of infertility patients regarding genetic carrier screening, embryo sex selection, embryo research, and gene editing.
Methods: An anonymous 32-question survey was distributed electronically to all patients who seen at a single academic fertility center for at least one visit between June 2018 and September 2019. Survey questions evaluated patient perspectives on genetic carrier screening, embryo sex selection, embryo research, and gene editing.
Background: COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) guidelines.
Methods: We conducted a single-center observational study of patients scheduled for "open-access colonoscopy"-ordered by a primary care provider without being seen in gastroenterology clinic-over a 6-week period during the COVID-19 pandemic.
Mutation screening of CDH1 is a standard of care for patients who meet criteria for Hereditary Diffuse Gastric Cancer (HDGC). In this setting, the classification of the sequence variants found in CDH1 is a critical step for risk management of patients with HDGC. In this report, we describe a germline CDH1 c.
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