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Publications by authors named "Alexander W J Renziehausen"

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Ablation of reactive astrocytes exacerbates disease pathology in a model of Alzheimer's disease.
Loukia Katsouri Amy M Birch Alexander W J Renziehausen Carolin Zach Yahyah Aman

Glia

May 2020

The role of astrocytes in the progression of Alzheimer's disease (AD) remains poorly understood. We assessed the consequences of ablating astrocytic proliferation in 9 months old double transgenic APP23/GFAP-TK mice. Treatment of these mice with the antiviral agent ganciclovir conditionally ablates proliferating reactive astrocytes.

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Synopsis of recent research by authors named "Alexander W J Renziehausen"

  • - Alexander W J Renziehausen's research primarily focuses on the role of astrocytes in the pathology of Alzheimer's disease, particularly their impact on disease progression.
  • - In a significant study published in May 2020, he investigated the effects of ablating reactive astrocytes in a mouse model of Alzheimer's disease, revealing critical insights into their contribution to disease exacerbation.
  • - The findings suggest that the removal of reactive astrocytes may worsen disease outcomes, indicating their complex role in neurodegenerative processes and potentially guiding future therapeutic strategies.

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