Publications by authors named "Alexander Vladimirovich Balatsky"
Correlations between biomarkers of senescent cell accumulation at the systemic, tissue and cellular levels in elderly patients.
Anna Grigorevna Sorokina Yana Arturovna Orlova Olga Aleksandrovna Grigorieva Ekaterina Sergeevna Novoseletskaya Nataliya Andreevna Basalova Alexander Vladimirovich Balatsky
Exp Gerontol
June 2023
The aim of the study was to investigate the relationship between established clinical systemic biomarkers of ageing and the development of age-associated diseases and senescent cell biomarkers at tissue and cellular levels. Thirty-eight patients (mean age 70 ± 4.9 years) who were assessed for traditional risk factors for cardiovascular diseases were included.
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- The study investigates two kits for isolating cell-free fetal DNA (cffDNA) from the blood of pregnant women and finds that the QIAamp Circulating Nucleic Acid Kit (CNAK) yields significantly more cffDNA and total cell-free DNA (cftDNA) compared to the QIAamp DSP Virus Kit (DSPVK).
- The researchers collected samples from 18 pregnant women and 12 unpregnant individuals, using digital PCR for quantifying the DNA yields.
- Results showed that while CNAK provided a higher yield of cffDNA, it also contained more PCR inhibitors, which could affect other analyses.