Publications by authors named "Alexander Valentin Nielsen"
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Synopsis of recent research by authors named "Alexander Valentin Nielsen"
- Alexander Valentin Nielsen's research primarily investigates the mechanisms of cell differentiation and reprogramming, particularly focusing on the transitions between different cellular states, such as extra-embryonic and embryonic endoderm lineages, using techniques including single-cell RNA sequencing.
- His findings reveal that chemical treatment can induce a "plastic state" in somatic cells, which facilitates their direct reprogramming into pluripotent stem cells, highlighting the role of transcription factors and chromatin accessibility in this process.
- Nielsen's earlier work also explores the dynamics of organ development, specifically in pancreatic organogenesis, demonstrating the heterogeneous contributions of progenitor cells driven by spatial and temporal cues during embryonic differentiation.
