Comparison of the Level of DNA-Hydrolyzing Polyclonal IgG Antibodies in Sera of Patients with Hashimoto's Thyroiditis and Nontoxic Nodal Goiter.

Various catalytically active IgG antibodies or abzymes have been recently detected in the sera of patients with several autoimmune pathologies, where their presence is most probably associated with autoimmunization. Here we show for the first time that IgG from peripheral blood of patients with Hashimoto's thyroiditis and nontoxic nodal goiter possesses DNase activity. The properties of the DNase IgGs distinguished them from other known human DNases.