Multi-channel electrical bioimpedance: a non-invasive method to simultaneously measure cardiac output and individual arterial limb flow in patients with cardiovascular disease.

Background: Cardiac output is the fundamental determinant of peripheral blood flow however; optimal regional tissue perfusion is ultimately dependant on the integrity of the arterial conduits that transport flow. A complete understanding of tissue perfusion requires knowledge of both cardiac and peripheral blood flow. Existing noninvasive devices do not simultaneously assess the cardiac and peripheral circulations.

Multi-channel electrical bioimpedance: a new noninvasive method to simultaneously measure cardiac and peripheral blood flow.

Objectives: We sought to assess the ability of a new multi-channel electrical bioimpedance (MEB) methodology to accurately measure both cardiac blood flow and peripheral limb blood flow.

Background: Cardiac output is the primary determinant of peripheral blood flow; however, optimal regional tissue perfusion is ultimately dependent on the patency of the arterial conduits that transport that flow. A complete understanding of regional tissue perfusion requires knowledge of both cardiac and peripheral blood flow.

Development of mass spectrometric method for analysis of cyclic nitramine explosives DTIW and HNIW.

Mass spectrometric (MS) methods are used for the analysis of two novel nitramine explosives-hexanitrohexaazaisowurzitane (HNIW) and 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurzitane (DTIW). The methods include electrospray (ESI) and atmospheric pressure chemical ionization techniques for liquid chromatography/MS (LC/MS), chemical ionization for direct introduction (DCI), and gas chromatography/MS (CI-GC/MS). It is found that HNIW (438 Da) is detectable using both positive and negative modes of DCI and in the negative mode ESI-MS.

A new charge derivatization procedure for peptide sequencing.

Derivatization of peptides by a trityl cation-containing group and collision-induced dissociation measurements of the cationized peptides results in informative spectra that simplify peptide sequencing.