A Novel Small Molecule Inhibitor of Biofilm Formation, Filamentation and Virulence with Low Potential for the Development of Resistance.

Background/objectives: is the principal causative agent of candidiasis, the most common fungal infection in humans. Candidiasis represents the third-to-fourth most frequent nosocomial infection worldwide, as this normal commensal of humans causes opportunistic infections in an expanding population of immune- and medically-compromised patients. These infections are frequently associated with biofilm formation, which complicates treatment and contributes to unacceptably high mortality rates.