Use of beta-blockers and risk of serious upper gastrointestinal bleeding: a population-based case-control study.

Background: Some studies indicate a reduced risk of serious upper gastrointestinal bleeding (UGIB) for users of beta-blockers, but the association remains to be confirmed in larger studies and characterized with respect to differences among beta-blockers. We aimed to assess whether beta-blocker use decreases the risk of UGIB.

Methods: We conducted a register-based, population-based case-control study in Denmark.