Publications by authors named "Alexander Stanforth"
Article Synopsis
- Ultra high dose rate (UHDR) radiotherapy, specifically conformal FLASH proton therapy, offers potential benefits by minimizing damage to healthy tissue while effectively targeting tumors.
- Clinical application of conformal FLASH has faced challenges, particularly concerning the quality assurance of measuring dose rate (DR) and linear energy transfer (LET).
- The study successfully validated these parameters, demonstrating strong agreement between experimental data and Monte Carlo simulations, confirming the efficacy of the UHDR treatment approach.
Purpose: Quality assurance computed tomography (QACT) is the current clinical practice in proton therapy to evaluate the needs for replan. QACT could falsely indicate replan because of setup issues that would be solved on the treatment machine. Deforming the treatment planning CT (TPCT) to the pretreatment CBCT may eliminate this issue.
View Article and Find Full Text PDFPurpose: In this study, we investigated computationally and experimentally a hexagonal-pattern array of spatially fractionated proton minibeams produced by proton pencil beam scanning (PBS) technique. Spatial fractionation of dose delivery with millimeter or submillimeter beam size has proven to be a promising approach to significantly increase the normal tissue tolerance. Our goals are to obtain an optimized minibeam design and to show that it is feasible to implement the optimized minibeams at the existing proton clinics.
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