Publications by Alexander Sands

Publications by authors named "Alexander Sands"

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Immunomodulation Followed by Antigen-Specific T Infusion Controls Islet Autoimmunity.

Cecilia Cabello-Kindelan Shane Mackey Alexander Sands Jennifer Rodriguez Claudia Vazquez

Diabetes

February 2020

Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4Foxp3 regulatory T cells (T) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded T in T1D and solid-organ transplant recipients are limited by poor T engraftment without host manipulation.

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- Alexander Sands focuses on developing immune-based therapies for type 1 diabetes (T1D), particularly emphasizing the role of CD4Foxp3 regulatory T cells in achieving long-term immune tolerance without chronic immunosuppression.
- His research highlights the challenges associated with expanding and engrafting these regulatory T cells in clinical settings, specifically in the context of T1D and solid-organ transplantation.
- The findings suggest that improved methods for host manipulation may enhance the effectiveness of regulatory T cell therapies, potentially leading to better management of autoimmune conditions like T1D.

Publications by authors named "Alexander Sands"

Immunomodulation Followed by Antigen-Specific T Infusion Controls Islet Autoimmunity.

Synopsis of recent research by authors named "Alexander Sands"