Publications by authors named "Alexander S Martinez"

Background: Uncovering the mechanisms underlying rapid genetic adaptation can provide insight into adaptive evolution and shed light on conservation, invasive species control, and natural resource management. However, it can be difficult to experimentally explore rapid adaptation due to the challenges associated with propagating and maintaining species in captive environments for long periods of time. By contrast, many introduced species have experienced strong selection when colonizing environments that differ substantially from their native range and thus provide a "natural experiment" for studying rapid genetic adaptation.

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The resistance of pest species to chemical controls has vast ecological, economic, and societal costs. In most cases, resistance is only detected after spreading throughout an entire population. Detecting resistance in its incipient stages, by comparison, provides time to implement preventative strategies.

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Populations of fishes are increasingly threatened by over-exploitation, pollution, habitat destruction, and climate change. In order to better understand the factors that can explain the amount of genetic diversity in wild populations of fishes, we collected estimates of genetic diversity (mean heterozygosity and mean rarefied number of alleles per locus) along with habitat associations, conservation status, and life-history information for 463 fish species. We ran a series of phylogenetic generalized least squares models to determine which factors influence genetic diversity in fishes after accounting for shared evolutionary history among related taxa.

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Article Synopsis
  • Aberrant calcium handling is a key issue in heart failure, and understanding its molecular mechanisms is crucial for developing treatments. The study highlights the role of peptidyl-prolyl isomerase 1 (Pin1) as a new regulator of calcium dynamics in heart cells.
  • Experiments show that deleting or inhibiting Pin1 slows down the decay of calcium in heart muscle cells, while unexpectedly increasing levels of calcium handling proteins like SERCA2a and Na/Ca exchanger 1, even though their actual activity is reduced.
  • The findings suggest that Pin1 interacts directly with these proteins, influencing their function and calcium handling, which might contribute to impaired heart muscle relaxation and could be relevant in tackling heart
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Background: Understanding patterns of biodiversity is a longstanding challenge in ecology. Similar to other biotic groups, arthropod community structure can be shaped by deterministic and stochastic processes, with limited understanding of what moderates the relative influence of these processes. Disturbances have been noted to alter the relative influence of deterministic and stochastic processes on community assembly in various study systems, implicating ecological disturbances as a potential moderator of these forces.

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