Publications by authors named "Alexander S Malogolovkin"
Article Synopsis
- The goose parvovirus (GPV) causes severe disease in young geese and ducks, leading to high mortality rates of 70-100% in naive groups, resulting in major losses for farmers.
- A study investigated the historical virulent GPV LIV-22 strain from 1972 and a developed attenuated vaccine strain, showing both belong to the classical GPV group but exhibit unique genetic changes.
- Microscopic analysis revealed significant cellular damage in infected geese shortly after exposure, providing insights into how GPV evolves and causes disease, which can aid future research on GPV's molecular pathogenesis.
Background: African swine fever (ASF) is a viral disease that affects pigs and wild boars providing economic burden in swine industry.
Methods And Results: In this study, we investigated the effect of deleting the ASFV multigene family 110 (MGF110) fragment (1 L-5-6 L) on apoptosis modulation and the expression of proinflammatory cytokines. Gene expression in swine peripheral blood macrophages infected with either the parental "Volgograd/14c" strain or the gene-deleted "Volgograd/D(1L-5-6L) MGF110" strain was analyzed.
Adeno-associated virus (AAV)-based therapies are recognized as one of the most potent next-generation treatments for inherited and genetic diseases. However, several biological and technological aspects of AAV vectors remain a critical issue for their widespread clinical application. Among them, the limited capacity of the AAV genome significantly hinders the development of AAV-based gene therapy.
View Article and Find Full Text PDF