Rapid, Controlled Branching Polymerization of Cyanoacrylate via Pathway-Enabled, Site-Specific Branching Initiation.

Controlled branched structures remain a key synthetic limitation for monomeric tissue adhesives because their on-site polymerization that enables adhesion formation requires rapid kinetics, high conversion, and straightforward setup. In this context, site-specific branching initiation by using evolmers is potentially effective for structural control; however, the efficiency and kinetics in current reaction setups persists to be a major challenge. In this paper, an evolmer induces a controlled branching polymerization of cyanoacrylate amid the high monomer reactivity useful in rapid adhesion.