Publications by authors named "Alexander Parajeles"
Article Synopsis
- Neuromyelitis optica spectrum disorders (NMOSD) present increasing diagnostic and treatment challenges in Latin America, with studies lacking comprehensive geographic outreach and demographic insights.
- A survey conducted by the Latin American Committee for Treatment and Research in MS gathered data from 62 experts across 21 countries, focusing on ethnic backgrounds, clinical characteristics, and diagnostic/therapeutic practices for NMOSD patients.
- The findings reveal that 2154 patients were reported, predominantly Mestizo (61.4%), with common symptoms including optic neuritis and transverse myelitis, and a high adherence (93.9%) to the 2015 International Panel for diagnosis.
Background: In this pooled, post hoc analysis of a phase 2 trial and the phase 3 TEMSO, TOWER, and TENERE clinical trials, long-term efficacy and safety of teriflunomide were assessed in subgroups of patients with relapsing multiple sclerosis (MS) defined by prior treatment status.
Methods: Patients were classified according to their prior treatment status in the core and core plus extension periods. In the core period, patients were grouped according to treatment status at the start of the study: treatment naive (no prior disease-modifying therapy [DMT] or DMT > 2 years prior to randomization), previously treated with another DMT (DMT > 6 to ≤24 months prior to randomization), and recently treated with another DMT (DMT ≤6 months prior to randomization).
Thrombotic disease is a multifactorial condition that involves both classical and genetic risk factors. We studied the association between the classical risk factors of hypertension and smoking, and polymorphisms on the genes of the angiotensin-converting enzyme (ACE), the beta-chain of fibrinogen (FG), and the plasminogen activator inhibitor-1 (PAI-1) in patients with venous and arterial thrombosis. The present investigation is a retrospective case-control study.
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