Publications by authors named "Alexander Pacolet"
Article Synopsis
- Prolonged mechanical loading significantly affects muscle plasticity and mechanosensing in skeletal muscles, particularly during a 14-day tail suspension study on mice.
- The triceps brachii showed a shift from fast to slow muscle fiber types, with enhanced mechanosensor gene and protein levels, alongside changes in transcription factors linked to these fiber types.
- Additionally, indicators of oxidative metabolism increased, suggesting improved muscle oxidative capacity, while markers related to protein synthesis also rose, highlighting the complex adaptive responses of muscles under sustained loading conditions.
Sedentary behavior has become ingrained in our society and has been linked to cardiovascular diseases. Physical inactivity is the main characteristic of sedentary behavior. However, its impact on cardiovascular disease is not clear.
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- - The study analyzed data from 703,901 individuals and identified 99 genetic loci related to physical activity levels and sedentary behavior, particularly focusing on leisure time activities and screen use.
- - Certain genes linked to sedentary behavior show heightened expression in skeletal muscle when influenced by resistance training, highlighting a connection between genetics and exercise.
- - The findings suggest that lower screen time and increased physical activity can positively impact health, but these effects may be influenced by factors like body mass index (BMI).
Background: Skeletal muscles (SkM) are mechanosensitive, with mechanical unloading resulting in muscle-devastating conditions and altered metabolic properties. However, it remains unexplored whether these atrophic conditions affect SkM mechanosensors and molecular clocks, both crucial for their homeostasis and consequent physiological metabolism.
Methods: We induced SkM atrophy through 14 days of hindlimb suspension (HS) in 10 male C57BL/6J mice and 10 controls (CTR).