Publications by authors named "Alexander P Gerhard"
Macrocyclic lactones (MLs) are widely used drugs to treat and prevent parasitic nematode infections. In many nematode species including a major pathogen of foals, , resistance against MLs is widespread, but the underlying resistance mechanisms and ML penetration routes into nematodes remain unknown. Here, we examined how the -glycoprotein efflux pumps, candidate genes for ML resistance, can modulate drug susceptibility and investigated the role of active drug ingestion for ML susceptibility in the model nematode .
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- P-glycoproteins (Pgps) are linked to macrocyclic lactone resistance in nematodes like Parascaris univalens, a key foal pathogen; ten genomic loci for Pgps were identified and characterized using RNA-seq and sequencing methods.
- Phylogenetic analysis uncovered a unique lineage of Pgps in ascarids, and while the intestine is a primary expression site for Pgps in both P. univalens and Caenorhabditis elegans, their expression patterns vary significantly between the two species.
- No increase in Pgp expression was found in P. univalens when exposed to ivermectin, indicating that the resistance does not involve drug-induced up