Publications by authors named "Alexander P Cherdantsev"

Article Synopsis
  • The study investigates how one or two doses of inactivated adjuvanted influenza vaccines affect immune responses, specifically focusing on the expression of endosomal Toll-like receptors (TLRs) in patients with common variable immunodeficiency (CVID).
  • Six CVID patients received one vaccine dose followed by nine patients who received two doses; flow cytometry was used to analyze immune cell populations and TLR expression.
  • Findings show that while key lymphocyte populations remained stable post-vaccination, patients receiving two doses exhibited increased TLR3 and TLR9 expression, indicating that two-dose vaccine regimens may enhance immune responses in CVID patients.
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Measles has not yet been eradicated; therefore, its outbreaks are still reported throughout the world. Like any infection, measles is dangerous for immunocompromised patients. Levels of anti-measles IgG antibodies were measured in 157 patients aged 17 to 72, who were placed on the lung transplant waiting list.

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Pregnant women are risk group for influenza infection. Results of new subunit vaccines application have not been studied enough. Prospective, randomized, open-label comparative study of subunit (Agrippal) and polymeric subunit (Grippol plus) vaccines.

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Pregnancy is a condition of modulated immune suppression, so this group of patients has increased risk of infectious diseases. Trivalent subunit vaccines, unadjusted Agrippal S1 (group I) and immunoadjuvant Grippol Plus (group II), containing 5 μg of actual influenza virus strains, were administered respectively to 37 and 42 women in the second and third trimester of physiological pregnancy. The administration of subunit influenza vaccines was accompanied by the development of local reactions in no more than 10% of patients, compared with 4.

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