Publications by authors named "Alexander Moreth"
Article Synopsis
- Cytostatic metallo-drugs typically bind to DNA nucleobases, but new dinuclear transition metal complexes are designed to target the phosphate diesters of DNA instead.
- The first dinuclear Ni complex shows different DNA binding characteristics compared to a similar Cu complex, leading to lower interference in DNA synthesis, especially in PCR, at lower concentrations.
- Cytotoxicity studies reveal that the Cu complex is more effective in killing cancer cells due to its ability to induce apoptosis, emphasizing the potential of these complexes as innovative anticancer treatments.
The mechanism of the cytotoxic function of cisplatin and related anticancer drugs is based on their binding to the nucleobases of DNA. The development of new classes of anticancer drugs requires establishing other binding modes. Therefore, we performed a rational design for complexes that target two neighboring phosphates of the DNA backbone by molecular recognition resulting in a family of dinuclear complexes based on 2,7-disubstituted 1,8-naphthalenediol.
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