Publications by authors named "Alexander Michael Curreri"
Adv Healthc Mater
August 2024
Article Synopsis
- mRNA is being explored as a treatment for various diseases, but traditional lipid nanoparticles (LNPs) used for delivery can cause safety and efficacy issues due to systemic exposure.
- A new delivery system using a deep eutectic solvent (cholinium malonate) enables precise control over mRNA expression levels at the injection site, allowing for a 68% increase in local muscle expression while reducing unwanted liver expression by 72%.
- This innovative approach enhances existing LNP formulations without needing complex lipid redesign, improving the targeted delivery of mRNA for potential medical applications.
