Publications by authors named "Alexander Melendez-Moreno"
Article Synopsis
- A study aimed to create a predictive model for diagnosing iris melanoma by analyzing data from 100 confirmed cases of melanoma and 112 cases of iris naevus.
- Researchers collected patient demographics, clinical features, and tumor characteristics and used Lasso logistic regression for analysis.
- The model identified key indicators of melanoma, achieving an optimism-corrected AUC of 0.865, and suggested that a prediction calculator app could improve diagnosis and patient communication, with potential for further improvement using more data.
Circadian rhythms in honey bees are involved in various processes that impact colony survival. For example, young nurses take care of the brood constantly throughout the day and lack circadian rhythms. At the same time, foragers use the circadian clock to remember and predict food availability in subsequent days.
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- Determining the difference between iris melanoma and iris nevus based on clinical exams is difficult, but the presence of tumor-associated blood vessels provides helpful diagnostic information.
- In a study involving 60 patients (45 with iris melanoma and 15 with iris nevi), researchers analyzed tumor characteristics and blood vessel patterns using clinical exams and fluorescein angiography.
- Results showed that feeder vessels were found only in melanomas, intrinsic vessels were more common in melanomas, and fluorescein leakage was significantly higher in melanomas, indicating that angiographic assessments can effectively differentiate between these types of tumors.
Uveal melanoma prognostication studies have mainly included posterior uveal melanomas located in the ciliary body and choroid, often excluding iris melanoma. In this study, we report prognostic status and survival outcomes in a series of 35 patients with biopsy-proven iris melanoma. Fluorescence in situ hybridization was performed in 10 (29%) cases and 2 (5%) underwent multiplex ligation-dependent probe amplification.
View Article and Find Full Text PDFIntroduction: Anterior uveal melanocytoma (AUM) pose a diagnostic challenge as they can mimic growing melanomas. Establishing a definitive diagnosis of melanocytoma necessitates cytologic or histopathologic confirmation. We describe the clinical presentation and characteristics of fifteen pathologically proven AUM cases and assess the role of fine needle aspiration biopsy (FNAB) as a safe and effective tool for diagnosis.
View Article and Find Full Text PDFHoney bees utilize their circadian rhythms to accurately predict the time of day. This ability allows foragers to remember the specific timing of food availability and its location for several days. Previous studies have provided strong evidence toward light/dark cycles being the primary Zeitgeber for honey bees.
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