Publications by authors named "Alexander McConnachie"
Article Synopsis
- Primary aldosteronism (PA) is a condition that can cause high blood pressure, often linked to a growth in the adrenal gland, and surgery can help fix it.
- A study compared a safer, non-invasive test called MTO scanning with a more invasive test called AVS to see which one does a better job at predicting successful surgery outcomes for people with PA.
- The results showed that the MTO scanning was just as good at predicting success as the invasive test, making it a useful option for diagnosing PA without the need for surgery first.
Background: Tumour necrosis factor (TNF) inhibition and B-cell depletion are highly effective treatments for active rheumatoid arthritis, but so far no randomised controlled trials have directly compared their safety, efficacy, and cost-effectiveness. This study was done to test the hypothesis that using rituximab would be clinically non-inferior and cheaper compared with TNF inhibitor treatment in biological-treatment naive patients with rheumatoid arthritis.
Methods: This open-label, randomised controlled, non-inferiority trial enrolled patients with active, seropositive rheumatoid arthritis and an inadequate response to synthetic disease modifying anti-rheumatic drugs (DMARDs) from 35 rheumatology departments in the UK.