An extraordinary colocalization of alopecia areata and vitiligo.

Although the association of alopecia areata (AA) and vitiligo occurring in the same patient has been frequently reported in the literature, the colocalization of AA and vitiligo is very rare. We report for the first time an adult patient with anatomic concurrence of AA and vitiligo on the scalp. Even though both AA and vitiligo are thought to have the same underlying pathophysiologic mechanisms, the striking rarity of their colocalization challenges this postulated common pathogenesis, and raises the question if autoimmunity is responsible for only a fraction of AA or vitiligo.

Mutations in lipase H cause autosomal recessive hypotrichosis simplex with woolly hair.

Background: Mutations in lipase H (LIPH) are a rare cause of autosomal recessive hypotrichosis (HT) simplex.

Objective: In this study, we investigated the clinical and molecular basis of HT simplex with woolly hair in 3 nonrelated families.

Methods: Three families of Jewish, Arab Muslim, and Italian origin that presented with HT with woolly hair were studied.

Severe skin reaction related to mycophenolate mofetil for myasthenia gravis.

The authors report the development of a papulosquamous psoriatic-like skin eruption following the introduction of mycophenolate mofetil (MM) in a patient with myasthenia gravis (MG). MM is a novel and potent immunosuppressive agent that blocks purine synthesis, thus selectively inhibiting T and B lymphocyte proliferation. Favorable results in refractory and steroid-dependent MG patients have been reported in open-label studies, revealing a rapid onset of action and a safe side effect profile.