Publications by authors named "Alexander Macke"
Article Synopsis
- Tissue-resident lymphocytes play a crucial role in defending organs against pathogens, but their response to vaccines in humans is less understood.
- A study analyzed SARS-CoV-2 mRNA vaccine-specific T cells from various organs and blood of largely virus-naive individuals, revealing higher numbers of specific CD4+ T cells in nonlymphoid tissues compared to blood.
- Findings suggest that vaccination leads to the development of memory T cells in organs far from the vaccination site, enhancing local immune protection in those tissues.
Neurotoxicity of anticancer agents complicates treatment of children with cancer. We investigated neurotoxic effects of common cytotoxic drugs in neuronal cultures and in the developing rat brain. When neurons were exposed to cisplatin (5-100 microM), cyclophosphamide (5-100 microM), methotrexate (5-100 microM), vinblastin (0.
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