Publications by authors named "Alexander M Surin"
Article Synopsis
- Stem cell technology is pivotal in regenerative medicine, utilizing stem/progenitor cells for repairing or replacing damaged tissues to treat various diseases like cardiovascular and neurological disorders.
- Cell therapy works through two main mechanisms: the replacement of damaged tissue and the release of biologically active molecules that aid in tissue regeneration, but challenges like transportation complexity and immune rejection exist.
- The study focuses on the beneficial effects of proteins secreted by glial progenitor cells, showing they can reduce inflammation and support neuron survival by inhibiting harmful factors and maintaining cellular health, potentially paving the way for new therapeutic applications.
Article Synopsis
- Brain injury causes neuroinflammation, high extracellular glutamate levels, and mitochondrial dysfunction, all contributing to neuronal death.
- The study analyzed patients with aneurysmal subarachnoid hemorrhage and conducted in vitro experiments to investigate the impact of these mechanisms on neuron health.
- Results indicate that the inhibition of the 2-oxoglutarate dehydrogenase complex by nitric oxide leads to increased extracellular glutamate and subsequent neuronal death, while thiamine can help reverse this toxicity.
The effect of DS16570511, a new inhibitor of mitochondrial calcium uniporter, on calcium homeostasis, metabolism, and functional state of cultured cortical neurons and isolated brain mitochondria.
Biochim Biophys Acta Gen Subj
May 2021
Background: Disorders of mitochondrial Ca homeostasis play a key role in the glutamate excitotoxicity of brain neurons. DS16570511 (DS) is a new penetrating inhibitor of mitochondrial Ca uniporter complex (MCUC). The paper examines the effects of DS on the cultivated cortical neurons and isolated mitochondria of the rat brain.
View Article and Find Full Text PDFNeural activity depends on the maintenance of ionic and osmotic homeostasis. Under these conditions, the cell volume must be regulated to maintain optimal neural function. A disturbance in the neuronal volume regulation often occurs in pathological conditions such as glutamate excitotoxicity.
View Article and Find Full Text PDFNeurotrophin-3 (NT-3) belongs to the family of highly conserved dimeric growth factors that controls the differentiation and activity of various neuronal populations. Mammals contain both the mature (NT-3) and the precursor (pro-NT-3) forms of neurotrophin. Members of the neurotrophin family are involved in the regulation of calcium homeostasis in neurons; however, the role of NT-3 and pro-NT-3 in this process remains unclear.
View Article and Find Full Text PDFATP in neurons is commonly believed to be synthesized mostly by mitochondria via oxidative phosphorylation. Neuronal mitochondria have been studied primarily in culture, i.e.
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