Rate normalization for sweat metabolomics biomarker discovery.

As the demand for real-time exercise performance feedback increases, excreted sweat has become a biosource of interest for continuous human performance assessment. For sweat to truly fulfill this requirement, analyte concentrations must be normalized to adequately assess day-to-day differences within and among individuals. In this manuscript, data are presented highlighting the use of accurate localized sweat rate as a means for ion and global metabolomic data normalization.

Evaluation of a standardized collection device for exhaled breath sampling onto thermal desorption tubes.

The Respiration Collector for In Vitro Analysis (ReCIVA) sampler, marketed by Owlstone Medical, provides a step forward in exhaled breath sampling through active sampling directly onto thermal desorption (TD) tubes. Although an improvement to the issues surrounding breath bag sampling, the ReCIVA device, first released in 2015, is a relatively new research and clinical tool that requires further exploration. Here, data are presented comparing two distinct ReCIVA devices.

Characterization of standardized breath sampling for off-line field use.

Due to several sources of potential variability associated with exhaled breath bag sampling procedures for off-line analysis, the Respiration Collector for in vitro Analysis (ReCIVA) sampler was developed. Although designed to improve upon several pitfalls of sampling with exhaled breath bags, the ReCIVA remains a minimally studied research tool. In this manuscript, several attributes of the ReCIVA sampler are investigated among three individual tests, such as background contamination, control software version, performance of different adsorbent tubes, duplicate sample production, and comparison to exhaled breath bags.

Effect of ambient light and age-related macular degeneration on precision walking.

Purpose: To determine how age-related macular degeneration (AMD) and changes in ambient light affect the control of foot placement while walking.

Methods: Ten older adults with AMD and 11 normal-sighted controls performed a precision walking task under normal (∼600 lx), dim (∼0.7 lx), and after a sudden reduction (∼600 to 0.

Effects of age-related macular degeneration and ambient light on curb negotiation.

Purpose: To determine how age-related macular degeneration (AMD) and changes in ambient light affect the ability to negotiate a curb while walking.

Methods: Ten older adults with AMD and 11 normal-sighted control subjects performed a curb negotiation task under normal light (∼600 lux), dim light (∼0.7 lux), and following a sudden reduction (∼600 to 0.

Changes in task parameters during walking prism adaptation influence the subsequent generalization pattern.

An understanding of the transfer (or generalization) of motor adaptations between legs and across tasks during walking has remained elusive due to limited research and mixed results. Here, we asked whether stepping sequences or task constraints introduced during walking prism-adaptation tasks influence generalization patterns. Forty subjects adapted to prism glasses in precision-walking or obstacle-avoidance tasks that required a specific stepping sequence to the center of two/three targets or laterally over an obstacle.

Prism adaptation and generalization during visually guided locomotor tasks.

The ability of individuals to adapt locomotion to constraints associated with the complex environments normally encountered in everyday life is paramount for survival. Here, we tested the ability of 24 healthy young adults to adapt to a rightward prism shift (∼11.3°) while either walking and stepping to targets (i.