Publications by authors named "Alexander M Dygai"
Article Synopsis
- The study investigates how dark deprivation influences liver health and circadian rhythms when exposed to carbon tetrachloride (CCl), a known hepatotoxic agent.
- While much is known about CCl's effects on the liver, research on its impact within the context of circadian rhythms is limited, and many studies focus on isolated periods rather than the overall rhythm.
- Findings suggest that dark deprivation leads to more severe structural and functional liver changes due to reduced melatonin levels, indicating the need for further research on the role of melatonin in these processes.
Objective: S-Adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are indicators of global transmethylation and may play an important role as markers of severity of COVID-19.
Methods: The levels of plasma SAM and SAH were determined in patients admitted with COVID-19 ( = 56, mean age = 61). Lung injury was identified by computed tomography (CT) in accordance with the CT0-4 classification.
Article Synopsis
- Aminothiols, like glutathione (GSH) and cysteinylglycine (CG), might be important in understanding the severity of COVID-19, but their exact role hasn't been fully explored yet.
- A study of 59 COVID-19 patients found that lower total glutathione (tGSH) levels were linked to a higher risk of severe illness and more lung damage, while levels of reduced cysteinylglycine (rCG) were also associated with lung injury.
- The findings suggest that tGSH and rCG could serve as useful indicators for assessing COVID-19 severity, highlighting the need to potentially adjust glutathione levels as part of treatment.
Gender Differences in the Pharmacological Actions of Pegylated Glucagon-Like Peptide-1 on Endothelial Progenitor Cells and Angiogenic Precursor Cells in a Combination of Metabolic Disorders and Lung Emphysema.
Int J Mol Sci
October 2019
In clinical practice, the metabolic syndrome (MetS) is often associated with chronic obstructive pulmonary disease (COPD). Although gender differences in MetS are well documented, little is known about sex-specific differences in the pathogenesis of COPD, especially when combined with MetS. Consequently, it is not clear whether the same treatment regime has comparable efficacy in men and women diagnosed with MetS and COPD.
View Article and Find Full Text PDFEndothelial Progenitor Cells as Pathogenetic and Diagnostic Factors, and Potential Targets for GLP-1 in Combination with Metabolic Syndrome and Chronic Obstructive Pulmonary Disease.
Int J Mol Sci
March 2019
In clinical practice, there are patients with a combination of metabolic syndrome (MS) and chronic obstructive pulmonary disease (COPD). The pathological mechanisms linking MS and COPD are largely unknown. It remains unclear whether the effect of MS (possible obesity) has a major impact on the progression of COPD.
View Article and Find Full Text PDFModulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice.
PLoS One
February 2016
Hyaluronidases are groups of enzymes that degrade hyaluronic acid (HA). To stop enzymatic hydrolysis we modified testicular hyaluronidase (HYAL) by activated polyethylene oxide with the help of electron-beam synthesis. As a result we received pegylated hyaluronidase (pegHYAL).
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