Synthesis of a C-C fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.

A convergent synthesis of a C-C fragment of the archazolids has been completed based on a high yielding Stille coupling to costruct the substituted ,,-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.