Publications by authors named "Alexander M Brannan"
Article Synopsis
- - The study investigates whether a synthetic amino acid sequence similar to the heparin binding domain (HBD) of human hepatic lipase (hHL) can effectively displace hHL from cell surfaces.
- - Researchers created a recombinant protein with the specific HBD and found that it successfully removed hHL from HEK-293 cells, while a scrambled peptide did not have this effect.
- - While the HBD peptide was largely unstructured, its interaction with heparin showed potential changes in structure, indicating that mimetic peptides could be useful for targeting cell surface lipases.
Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also has a striking effect on ribosomes.
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