Publications by authors named "Alexander Luke Button"
Genome-wide Association Studies of Retinal Vessel Tortuosity Identify Numerous Novel Loci Revealing Genes and Pathways Associated With Ocular and Cardiometabolic Diseases.
Mattia Tomasoni Michael Johannes Beyeler Sofia Ortin Vela Ninon Mounier Eleonora Porcu Alexander Luke Button
Ophthalmol Sci
September 2023
Article Synopsis
- The study aims to find new genetic factors linked to variations in retinal vascular tortuosity, which could help in understanding its impact on certain diseases and their risk factors.
- The research involved analyzing a large dataset of retinal images from over 63,000 participants, utilizing advanced imaging techniques and deep learning for accurate measurement of vessel tortuosity.
- Results showed a significant connection between higher retinal tortuosity and various cardiovascular issues, leading to the identification of 175 genetic loci related to this trait, which could inform future medical studies and interventions.