Medication-Related Osteonecrosis of the Jaw in Cancer Patients: Result from the OneFlorida Clinical Research Consortium.

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severely debilitating drug-induced bone disorder in the jawbone region. The first MRONJ was reported in 2003 after bisphosphonate (BP) exposure. Recently, other drugs, such as receptor activator of NF-κB ligand (RANKL) inhibitor denosumab and antiangiogenic agents, were also associated with MRONJ.

Assessing the practice of data quality evaluation in a national clinical data research network through a systematic scoping review in the era of real-world data.

Objective: To synthesize data quality (DQ) dimensions and assessment methods of real-world data, especially electronic health records, through a systematic scoping review and to assess the practice of DQ assessment in the national Patient-centered Clinical Research Network (PCORnet).

Materials And Methods: We started with 3 widely cited DQ literature-2 reviews from Chan et al (2010) and Weiskopf et al (2013a) and 1 DQ framework from Kahn et al (2016)-and expanded our review systematically to cover relevant articles published up to February 2020. We extracted DQ dimensions and assessment methods from these studies, mapped their relationships, and organized a synthesized summarization of existing DQ dimensions and assessment methods.

Implementing a hash-based privacy-preserving record linkage tool in the OneFlorida clinical research network.

Objective: To implement an open-source tool that performs deterministic privacy-preserving record linkage (RL) in a real-world setting within a large research network.

Materials And Methods: We learned 2 efficient deterministic linkage rules using publicly available voter registration data. We then validated the 2 rules' performance with 2 manually curated gold-standard datasets linking electronic health records and claims data from 2 sources.