Publications by Alexander L Metz

Publications by authors named "Alexander L Metz"

Page 1 of 1

Differential Effects of Clinically Relevant N- versus C-Terminal Truncating CDKN1A Mutations on Cisplatin Sensitivity in Bladder Cancer.

Rahmat K Sikder Moataz Ellithi Robert N Uzzo David J Weader Alexander L Metz

Mol Cancer Res

March 2021

Muscle-invasive bladder cancer (MIBC) frequently harbors mutations in the gene, which encodes the tumor suppressor protein p21, with the majority of alterations truncating the peptide. The effect of these mutations is poorly understood. We hypothesized that after DNA-damaging events, cells deficient in p21 would be unable to halt the cell cycle and efficiently repair DNA damage, thus proceeding down the apoptotic pathway.

View Article and Find Full Text PDF

Alexander L Metz's recent research focuses on understanding the impact of specific mutations in the CDKN1A gene, particularly their effects on cisplatin sensitivity in muscle-invasive bladder cancer (MIBC).
His study examines how N- and C-terminal truncating mutations in the p21 protein influence cellular responses to DNA damage, with implications for cancer treatment strategies.
The findings suggest that cells with p21 deficiencies, due to these mutations, could struggle to repair DNA damage and are more likely to undergo apoptosis, highlighting the importance of p21 in maintaining cell cycle regulation and response to chemotherapy.

Publications by authors named "Alexander L Metz"

Differential Effects of Clinically Relevant N- versus C-Terminal Truncating CDKN1A Mutations on Cisplatin Sensitivity in Bladder Cancer.

Synopsis of recent research by authors named "Alexander L Metz"