Randomized multicenter noninferiority phase III clinical trial of the first biosimilar of eculizumab.

Currently, eculizumab is the main effective treatment for paroxysmal nocturnal hemoglobinuria (PNH). The aim of this randomized multicenter noninferiority study was to evaluate the efficacy and safety of the Biosimilar (Elizaria) in comparison with the Originator (Soliris) in patients with PNH. Biosimilar and Originator were administered at a dose of 600 mg weekly for 4 weeks at the initial stage in naive patients, as well as for maintenance therapy at a dose of 900 mg every 2 weeks in all patients.

Hydroelastic wave diffraction by a vertical cylinder.

A linear three-dimensional problem of hydroelastic wave diffraction by a bottom-mounted circular cylinder is analysed. The fluid is of finite depth and is covered by an ice sheet, which is clamped to the cylinder surface. The ice stretches from the cylinder to infinity in all lateral directions.

The mathematical challenges and modelling of hydroelasticity.

Hydroelasticity brings together hydrodynamics and elastic theories. It is concerned with deformations of elastic bodies responding to hydrodynamic excitations, which themselves depend on elastic deformation. This Theme Issue is intended to identify and to outline mathematical problems of modern hydroelasticity and to review recent developments in this area, including physically and mathematically elaborated models and the techniques used in their analysis.