Publications by authors named "Alexander Klon"
Proc Natl Acad Sci U S A
December 2024
Article Synopsis
- The oxidative pentose phosphate (OPP) pathway is crucial for generating metabolites and reducing power in cells, with its initial reactions supporting the Calvin-Benson cycle.
- Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme in this pathway, regulated by the redox protein OpcA in cyanobacteria, showing different activity based on OpcA's oxidation state.
- Research using cryogenic electron microscopy revealed that OpcA interacts with G6PDH, causing structural changes that fine-tune G6PDH activity depending on the amount of OpcA bound, highlighting a sophisticated regulatory mechanism in the OPP pathway.
