Synopsis of recent research by authors named "Alexander Kirschenbaum"
- Alexander Kirschenbaum's research primarily focuses on the mechanisms of prostate cancer progression and metastasis, particularly the interactions between genetic factors like c-MYC and KLF6-SV1, which have been shown to induce phenotypic plasticity in cancer cells and enhance metastatic potential.
- A significant portion of his studies addresses bone metastasis in prostate cancer, revealing how prostatic acid phosphatase influences osteoblastic activity, complicating treatment options due to the unique bone-targeting nature of the disease.
- Kirschenbaum also explores therapeutic interventions for castration-resistant prostate cancer, including small-molecule activators of protein phosphatase 2A, which demonstrate growth-inhibitory effects on cancer cells by modulating oncogenic signaling pathways.
