Bi- and trimetallic complexes with macrocyclic xanthene-4,5-diNHC ligands.

Three different types of bimetallic NHC-metal complexes were synthesized, whose NHC units are attached at the 4,5-positions of xanthene. The NHC units are in close proximity and are designed such that each carbene coordinates one ML unit, while the chelation of one metal by two NHC is not possible. Several xanthene-((NHC)ML) complexes with ML = RhCl(cod), IrCl(cod), RhCl(CO), IrCl(CO), AuCl, AgCl, CuCl and Pd(allyl)Cl were synthesized and investigated.

Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening.

Leuktriene B4 receptor 2 (BLT2) is a G-protein coupled receptor modulation of which is discussed to be a therapeutic option for healing of intestinal lesions. In this work, new BLT2 agonists were identified by a virtual screening of a repurposing library and assay of the most promising compounds. Irbesartan, an approved type-1 angiotensin II receptor (AT1) antagonist, was identified as a moderate BLT2 agonist.

First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters.

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12()-hydroxyheptadeca-5,8,10-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented.

Predictors and determinants for weight reduction in overweight and obese children and adolescents.

Introduction: Worldwide, overweight and obesity are known as posing serious health risks. Successful methods for weight reduction have remained elusive. This multicenter non-randomised trial aimed to identify parameters and determinants of long-term weight reduction.

Identification of Predictors for Weight Reduction in Children and Adolescents with Overweight and Obesity (IDA-Insel Survey).

Introduction: Worldwide, overweight and obesity are known as posing serious health risks. Successful methods of prevention and therapy for overweight and obesity have remained elusive. It was the aim of the present trial to identify parameters and determinants to guarantee long-term weight reduction.

Impact of information technology on the therapy of type-1 diabetes: a case study of children and adolescents in Germany.

Being able to manage and adjust insulin doses is a key part of managing type-1 diabetes. Children and adolescents with type-1 diabetes mellitus often have serious difficulties with this dosage adjustment. Therefore, this paper aims to investigate the impact of using novel mobile, web and communication technologies in assisting their therapy and treatment.

Electronic health technology for the assessment of physical activity and eating habits in children and adolescents with overweight and obesity IDA.

Objective: It was the goal of the trial to study the impact of electronic healthcare technology into treatment.

Methods: One hundred and twenty-four children/adolescents (females 56%, age 13.5±2.

Identification of determinants for weight reduction in overweight and obese children and adolescents.

We conducted a pilot trial of electronic technology integrated into the treatment of children and adolescents who are overweight or obese. A total of 30 patients (mean age 14 years, mean BMI 32.7 kg/m(2)) were admitted to our hospital to participate in a structured treatment and teaching programme (STTP).