TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and .

TOLLIP is a central regulator of multiple innate immune signaling pathways, including TLR2, TLR4, IL-1R, and STING. Human TOLLIP deficiency, regulated by single-nucleotide polymorphism rs5743854, is associated with increased tuberculosis risk and diminished frequency of bacillus Calmette-Guérin vaccine-specific CD4 T cells in infants. How TOLLIP influences adaptive immune responses remains poorly understood.